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Substance use disorders genetics

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Flagship Project

Substance Use Disorders Genetics

We have explored the polygenic contributions of substance use disorders (alcohol, cannabis) across multiple medical phenotypes.

 

Our primary site has been BioVU, but it would be fantastic to replicate some of these findings across any other site that may be interested.

Publications:
Zhou H, Sealock J, Sanchez-Roige S, Clarke TK, Levey DF, Cheng Z, Li B, Polimanti R, Kember RL, Smith RV, Thygesen JH, Morgan MY, Atkinson SR , Thursz MR, Nyegaard M, Mattheisen M, Børglum AD, Johnson EC, Justice AC, Palmer AA, McQuillin A, Davis LK, Edenberg HJ, Agrawal A, Kranzler HR, Gelernter J (2020) Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits. Nature Neuroscience doi.org/10.1038/s41593-020-0643-5.

 

Johnson EC, Demontis D, Thorgeirsson TE, Walters RK, Polimanti R, Hatoum AS, Paul SE, Clarke TK, Sanchez-Roige S, Lai D, Reginsson GW, Zhou H, Adkins AE, Adkins DE, Alexander J, Bacanu SA, Baranger DAA, Bierut LJ, Bigdeli TB, Boardman JD, Boden J, Brown SA, Bucholz KK, Copeland WE, Costello EJ, Degenhardt L, Dick DM, Domingue BW, Farrer LA, Foroud TM, Fox L, Gillespie NA, Goate AM, Grucza RA, Hack LM, Hancock DB, Harris KM, Hartz SM, Heath AC, Hesselbrock V, Hewitt JK, Hopfer CJ, Horwood J, Gudbjartsson DF, Iacono WC, Johnson EO, Kendler KS, Kennedy MA, Kranzler HR, Krauter K, Madden PAF, Maes HH, Maher BS, Martin NG, McClintick JN, McGue M, McQueen MB, Meyers JL, Montgomery G, Nelson EC, Pearson JF, Peterson RE, Porjesz B, Reynolds MD, Rice JP, Riley BP, Runarsdottir V, Saccone NL, Sherva R, Silberg JL, Stallings MC, Tarter RE, Tyrfingsson T, Vanyukov MM, Vrieze S, Wall TL, Webb BT, Wedow RL, Wetherill L, Whitfield J, Zellers S, the Psychiatric Genomics Consortium Substance Use Disorders Workgroup, Bogdan R, Stefansson K, Børglum AD, Gelernter J, Edenberg HJ, Agrawal A (2020) A large-scale genome-wide association study meta-analysis of cannabis use disorder. Lancet Psychiatry doi: 10.1016/S2215-0366(20)30339-4

 

Mallard T, Savage JE, Johnson EC, Huang Y, Edwards AC, Hottenga JJ, Grotzinger AD, Gustavson DE, Jennings MV, Anokhin A, Dick DM, Edenberg HJ, Kramer JR, Lai D, Meyers JL, Pandey AK, Harden KP, Nivard MJ, de Geus EJC, Boomsma DI, Agrawal A, Davis LK, Clarke TK, Palmer AA & Sanchez-Roige S (2021) Item-level genome-wide association study of the Alcohol Use Disorders Identification Test in three population-based cohorts. American Journal of Psychiatry In Press

Sanchez-Roige S, Cox NJ, Johnson EO, Hancock DB, Davis LK. (2021) Alcohol and cigarette smoking consumption as genetic proxies for alcohol misuse and nicotine dependence. Drug Alcohol Dependence doi.org/10.1016/j.drugalcdep.2021.108612


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